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MEDICATION Guide
Bupropion Hydrochloride (ZYBAN® Sustained-Release Tablets)

Specifics About Bupropion/Zyban®

What is the product strength?
Zyban® Sustained-Release Tablets contain 150 mg of bupropion hydrochloride, in purple, round, biconvex, film-coated tablets.

What is the recommended treatment duration?
The manufacturer of Zyban® recommends a treatment duration of at least 7 - 12 weeks. For long-term therapy, consider use of Zyban® for up to 6 months post-quit, which is FDA approved.

What are the adverse reactions and cautionary messages?
Side effects from taking bupropion include:

  • Most common: insomnia (35-40%) and dry mouth (10%). If insomnia is marked, taking the PM dose earlier (in the afternoon, at least 8 hours after the first dose) may provide some relief.
  • Less common: anxiety, changes in appetite, constipation, diarrhea, dizziness, drowsiness, headache, increased sweating, nausea, stomach pain, stuffy nose, weight changes.

There are specific conditions that would warrant against the use of bupropion. You should discuss your medical history with a physician prior to using this drug; note:

  • History of seizure disorder or serious head injury
  • History of bipolar mental illness
  • Current use of Wellbutrin®, Wellbutrin SR® or other medications containing bupropion
  • Current or prior diagnosis of bulimia or anorexia nervosa
  • Use of a monoamine oxidase inhibitor within the previous 14 days
  • Allergic response to bupropion

What should I avoid while taking bupropion?

  • Do not drink a lot of alcohol while taking bupropion. If you usually drink a lot, talk with your doctor before suddenly stopping. If you suddenly stop drinking alcohol, you may increase your chance of having seizures.
  • Do not drive a car or use heavy machinery until you know how bupropion affects you. Bupropion can affect your ability to do these things safely.

If you are considering using bupropion, first read this information from the National Institutes of Health and see your doctor:


Content author: Alan S. Peters, CTTS-M
Reviewed by: Ann Wendling, MD, MPH, April 2013

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